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3 H‐spiperone binding in platelet membranes: a possible biological marker for schizophrenia
Author(s) -
Sethi B. B.,
Kumar P.,
Agarwal A. K.,
Seth P. K.,
Trivedi J. K.
Publication year - 1986
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1986.tb10585.x
Subject(s) - spiperone , schizophrenia (object oriented programming) , psychosis , platelet , dissociation constant , psychology , antipsychotic , brief psychiatric rating scale , medicine , rating scale , endocrinology , chemistry , psychiatry , receptor , developmental psychology , antagonist
— High‐affinity‐specific IH‐spiperone binding to platelet membranes was carried out in 30 schizophrenic patients, without prior antipsychotic medication, fulfilling the Research Diagnostic Criteria, and in 30 matched control subjects. The psychosis was rated on the Modified Brief Psychiatric Rating Scale. Compared with healthy subjects, schizophrenic patients had significantly higher 3 H‐spiperone binding due to a lower dissociation constant (38%), i.e. increased affinity. NO significant difference was observed in the maximum number of binding sites (B max ) between the two groups. It is our contention that IH‐spiperone binding to platelets may be a biological marker for schizophrenia.