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The effects of repeated doses of temazepam and nitrazepam on several measures of human performance
Author(s) -
Griffiths A. N.,
Tedeschi G.,
Richens A.
Publication year - 1986
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1986.tb08988.x
Subject(s) - temazepam , nitrazepam , psychology , medicine , pharmacology , diazepam , benzodiazepine , receptor
The effects of six nightly doses of temazepam (20 mg), nitrazepam (10 mg) and placebo on saccadic eye movements, critical flicker fusion threshold, choice reaction time and mood were studied in eight volunteers. Performance was measured on nights 1 and 6 of each treatment. Nitrazepam produced a residual performance impairment on night 1 that disappeared by night 6, despite higher serum concentrations of the drug on the sixth night of treatment. Temazepam, with a shorter elimination half‐life, produced no significant performance impairment on night 1, but by night 6 a significant impairment of saccadic eye movements ( p < 0.05) was seen 1 hour after drug intake. We conclude that tolerance to the sedative action of nitrazepam developed over the 6‐night period of the study. No evidence of tolerance was seen with temazepam. No residual effects of temazepam (20 mg) were seen the morning after the night‐time drug administration.