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3‐MHPG as a non‐predictor of antidepressant response to imipramine and electroconvulsive therapy
Author(s) -
Sharma I. J.,
Venkitasubramanian T. A.,
Agnihotri B. R.
Publication year - 1986
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1986.tb06241.x
Subject(s) - imipramine , electroconvulsive therapy , antidepressant , rating scale , hamilton rating scale for depression , excretion , depression (economics) , medicine , psychology , major depressive disorder , electroconvulsive shock , developmental psychology , alternative medicine , pathology , amygdala , hippocampus , economics , macroeconomics
The urinary excretion of 3‐methoxy, 4‐hydroxyphenyl‐glycol, (3‐MHPG) was measured in 20 unipolar depressed patients before treatment with imipramine and electroconvulsive therapy (ECT) to investigate the relationship between pretreatment urinary excretion of 3‐MHPG and clinical response. There was no difference in 3‐MHPG excretion for depressed patients and controls. There was no significant difference between the mean percentage reduction of Hamilton Depression Rating Scale Scores in “low” and “high” excretors of 3‐MHPG in the imipramine and ECT group of patients after four weeks of treatment.