Premium
Controversies and Consistencies in Psychiatric Genetics
Author(s) -
BERTELSEN A
Publication year - 1985
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1985.tb08523.x
Subject(s) - twin study , schizophrenia (object oriented programming) , heritability , psychiatric genetics , psychosis , psychiatry , psychology , family studies , disease , endophenotype , bipolar disorder , medicine , genetics , biology , cognition , pathology
: The methodology in psychiatric genetics, including family studies, twin studies, and adoption strategies, developed during the last 70 years to a high degree of perfection, has established beyond doubt the heritability of the major psychoses, the schizophrenic and manicdepressive disorders. In spite of recent refinements, including twin‐family‐study strategies, dual mating strategies, and advanced mathematical models and statistics the mode of inheritance is stil undetermined. Evidence for heterogeneity in both schizophrenia and manic‐depressive psychosis has been brought up leading to new approaches in diagnostic delimitations. However, the final solution of this issue probably has to await the finding of a genetic marker, for which recent advances in molecular biology as seen in Huntigton's disease may give some hope.