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A double‐blind group comparison of mianserin and clomipramine in the treatment of mildly depressed psychiatric out‐patients
Author(s) -
Dunbar G.C.,
Naarala M.,
Hiltunen H.
Publication year - 1985
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1985.tb08077.x
Subject(s) - clomipramine , mianserin , anxiolytic , antidepressant , somatization , anxiety , depression (economics) , psychology , anesthesia , medicine , incidence (geometry) , rating scale , psychiatry , developmental psychology , physics , macroeconomics , optics , economics
The effects of mianserin 30–60 mg and clomipramine 75–150 mg were compared in a randomized double‐blind study of 62 mildly depressed outpatients. Treatment was continued for three to four weeks, after which approximately 50% of patients left the study clinically much improved. Significant benefits for mianserin were apparent at days 7 and 21 on the Hamilton Depression Rating Scale (HDRS) total score and at day 7 on the HDRS anxiety‐somatization factor score. No difference in overall antidepressant activity was found in those patients treated for four weeks. There was a significantly greater number of side‐effects in the clomipramine treated group. It is suggested that mianserin is a more rational treatment than clomipramine in this group of patients because of a greater anxiolytic action and a lower incidence of side‐effects.