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DST in healthy volunteers and after sleep deprivation
Author(s) -
Klein H. E.,
Seibold B.
Publication year - 1985
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1985.tb02564.x
Subject(s) - sleep deprivation , psychology , privation , medicine , dexamethasone suppression test , sleep (system call) , endocrinology , circadian rhythm , dexamethasone , computer science , operating system
– The dexamethasone suppression test (DST) was performed in 46 healthy volunteers and repeated in nine of them following total sleep deprivation (TSD). While only 2 postdexamethasone cortisol values were insufficiently suppressed (> 5 μg%) in control DSTs, 5 postdexamethasone cortisol values were above 5 μg% following TSD. The mean postdexamethasone value was increased from 1.55 ± 1.06 to 4.47 ± 5.86 μg% following TSD at 8.00 h. The authors conclude that sleep deprivation as a therapeutic approach and prolonged sleeplessness may bias DST results.