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A double‐blind group comparative study using the new anti‐depressant Org 3770, placebo and diazepam in patients with expected insomnia and anxiety before elective gynaecological surgery
Author(s) -
Bettum V.,
Sørensen M.,
Jørgensen J.,
VibyMogensen J.,
Dunbar G. C.,
Steffensen K.
Publication year - 1985
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1985.tb02533.x
Subject(s) - placebo , diazepam , evening , anxiety , anesthesia , morning , insomnia , medicine , hypnotic , elective surgery , alprazolam , psychology , psychiatry , physics , alternative medicine , pathology , astronomy
Two hundred and fifty female patients about to undergo elective gynaecological surgery, were randomly allocated to a single oral dose of either 5, 15, 30 mg Org 3770, placebo, or 10 mg diazepam the evening before operation. Assessment of sleep quality next morning using self‐rated questionnaires showed that both Org 3770 and diazepam were significantly better than placebo in enhancing sleep. In addition, a dose‐response effect was seen with Org 3770, 15 mg seeming optimal. Assessment of pre‐surgery anxiety, again using self‐rated questionnaires, showed that 15 mg Org 3770, and 10 mg diazepam were significantly more effective than placebo at reducing anxiety. None of the medications produced any troublesome side effects nor did they have an effect on blood pressure.