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Effects of Sulpiride on Persistent Neuroleptic‐induced Dyskinesia in Monkeys
Author(s) -
Häggström JE
Publication year - 1984
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1984.tb06862.x
Subject(s) - sulpiride , dyskinesia , tardive dyskinesia , metoclopramide , anticholinergic , dystonia , anesthesia , anticholinergic agents , medicine , psychology , dopamine antagonist , paroxysmal dyskinesia , haloperidol , antagonist , psychiatry , schizophrenia (object oriented programming) , dopamine , parkinson's disease , receptor , disease , vomiting
Five Cebus apella monkeys with persistent neuroleptic‐induced dyskinesia were given a single dose of sulpiride (20 mg/kg i.m.). The dyskinesia was reduced in all five although four developed attacks of acute dystonia which had to be reversed by anticholinergic medication in three animals. In one monkey the administration of classic neuroleptics had earlier been shown to induce a typical sequence of events. First there was a similar reduction of dyskinesia as seen in the other monkeys, 1–2 days later there was noticed a rebound deterioration lasting for several days. Metoclopramide 0.5 mg/kg, caused such a rebound effect (for 2 days), whereas sulpiride did not.