Premium
Linkage between X‐chromosome markers and manic‐depressive illness
Author(s) -
Zompo M. Del,
Bocchetta A.,
Goldin L. R.,
Corsini G. U.
Publication year - 1984
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1984.tb01210.x
Subject(s) - pedigree chart , linkage (software) , penetrance , genetic linkage , x chromosome , genetics , psychology , bipolar disorder , psychiatry , medicine , lithium (medication) , biology , gene , phenotype
– Pedigrees of manic‐depressive patients in treatment at the Lithium Clinic of the Institute of Clinical Pharmacology, University of Cagliari, were evaluated for linkage between major affective illness and the protan‐deulan‐glucose‐6‐phosphatc‐dehydrogenase region of the X‐chromosome. Two informative pedigrees were found, investigated and analyzed for linkage using a multigenerational model and considering age‐dependent penetrance. The results are consistent with the hypothesis of X‐linkage in major affective illness.