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Effects of amitriptyline, desipramine and zimeldine, alone and in combination with ethanol, on information processing and memory in healthy volunteers
Author(s) -
Linnoila M.,
Johnson J.,
Dubyoski T.,
Ross R.,
Buchsbaum M.,
Potter W. Z.,
Weingartner H.
Publication year - 1983
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1983.tb11121.x
Subject(s) - desipramine , amitriptyline , psychology , alcohol , working memory , cognition , ethanol , task (project management) , anesthesia , medicine , psychiatry , antidepressant , chemistry , anxiety , biochemistry , management , organic chemistry , economics
— Interactions of three antidepressants — amitriptyline, desipramine and zimeldine — with a single 0.8 g/kg body weight dose of alcohol were studied in healthy male volunteers. The dependent variables were performance measurements in the Continuous Performance Task and a cognitive memory task. Alcohol and desipramine showed different and specific deleterious effects on cognitive and memory functions, whereas amitriptyline produced a more generalized impairment. Zimeldine slightly improved performance in the Continuous Performance Task and antagonized effects of alcohol in both tasks.