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Effects on the regional cerebral blood flow of long‐term exposure to organic solvents
Author(s) -
And J. Risberg,
Hagstadius S.
Publication year - 1983
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1983.tb00945.x
Subject(s) - cerebral blood flow , inhalation , psychology , anesthesia , medicine , physiology , cardiology
Regional cerebral blood flow (rCBF, 133 Xe inhalation method) was measured in 50 male paint‐factory workers with a mean of 18 years of exposure to a mixture of organic solvents. A group of 50 workers in a sugar‐refinery, matched for age and eduction, served as controls. The measurements were made during resting and during activation by mental tasks (word‐pair learning). The results showed slightly lower mean flow level (4%; P < 0.05) in the exposed group. Largest differences were seen in frontotemporal areas. The difference between the exposed group and the controls increased at higher dose levels. The largest rCBF‐increases during mental activation were seen in the exposed group, especially in the highest exposed subjects. This finding might indicate mechanisms compensating for a somewhat defective brain function. Although the differences between the groups were generally small with considerable overlap, the results give some evidence of disturbances of brain blood flow and brain function likely related to the influence of organic solvents.