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Liver function under long‐term treatment with neuroleptic drugs assessed by serum concentrations of bile acids, alkaline phosphatase, and aspartate aminotransferase
Author(s) -
Linnet K.,
Andersen J. Rye,
Mørup L.
Publication year - 1983
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1983.tb00348.x
Subject(s) - alkaline phosphatase , liver function , medicine , alanine aminotransferase , endocrinology , liver function tests , bile acid , chemistry , biochemistry , enzyme
‐ Serum concentrations of total 3a‐hydroxy‐bile acids, alkaline phosphatase, and aspartate aminotransferase were measured in 35 psychotic patients who had been under treatment with neuroleptic drugs for more than 1 year. Serum concentrations of total bile acids were from 1.0 to 9.4 μ mol/l (mean 2.9 μ mol/l) in the patients and from 0.6 to 4.8 μ mol/l (mean 2.2 μ mol/l) in 20 healthy controls; the mean values were not significantly different. Serum concentrations of alkaline phosphatase and aspartate aminotransferase in patients and controls were not significantly different either. In conclusion, none of the patients had signs of manifest hepatobiliary dysfunction.