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Urinary excretion of 5‐hydroxyindoleacetic acid – no relationship to the level in cerebrospinal fluid
Author(s) -
Bertilsson L.,
Tybring G.,
Braithwaite R.,
TräskmanBendz L.,
ÅSberg M.
Publication year - 1982
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1982.tb00927.x
Subject(s) - 5 hydroxyindoleacetic acid , cerebrospinal fluid , excretion , urine , urinary system , medicine , endocrinology , serotonin , receptor
Concentrations of 5‐hydroxyindoleacetic acid (5‐HIAA) were determined in urine and cerebrospinal fluid (CSF) by mass fragmentography. A pronounced day‐to‐day variation in the urinary excretion of 5‐HIAA was found both in psychiatric patients and a healthy control. Lumbar punctures performed twice 3–12 weeks apart in 11 healthy controls resulted in reproducible levels of 5‐HIAA in CSF ( r = 0.89; P < 0.001). The mean of three periods of daily 5‐HIAA excretion was not correlated to the CSF level measured in 18 psychiatric patients ( r =–0.09). Three weeks of chlorimipramine treatment significantly decreased CSF 5‐HIAA levels ( P < 0.05), but not the urinary excretion of 5‐HIAA. It might be concluded that measurement of urinary 5‐HIAA excretion is of little value compared to CSF levels in studies of serotonin in the central nervous system.