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Genetic models of schizophrenia
Author(s) -
Baron M.
Publication year - 1982
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1982.tb00846.x
Subject(s) - inheritance (genetic algorithm) , locus (genetics) , genetic model , multifactorial inheritance , population , paranoid schizophrenia , genetics , schizophrenia (object oriented programming) , biology , psychology , psychosis , psychiatry , gene , medicine , single nucleotide polymorphism , genotype , environmental health
Multiple threshold models of inheritance are applied to a large sample of Franz Kallmann's (1938) pedigree data on schizophrenia. Paranoid and nonparanoid subtypes are represented in the models at different thresholds on a continuum of genetic‐environmental liability. Single major locus and multifactorial‐polygenic inheritance are ruled out as modes of transmission. These findings suggest that the paranoid‐non‐paranoid dichotomy cannot be used as a genetic threshold determinant in the population studied.