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Comparison of nitrazepam with triazolam in insomniac outpatients
Author(s) -
Dahl L. E.,
Dencker S. J.,
Lundin L.,
Kullingsjö H.
Publication year - 1982
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1982.tb00826.x
Subject(s) - triazolam , nitrazepam , hypnotic , anesthesia , lorazepam , psychology , sleep (system call) , medicine , benzodiazepine , diazepam , receptor , computer science , operating system
The short‐acting hypnotic, triazolam 0.5 mg, was compared in a 7‐day double‐blind study with the longer acting drug, nitrazepam 5 mg. Of the 60 patients enrolled, 29 in each drug treatment group completed the study and were evaluated. All significant differences found favoured triazolam. On the first night, triazolam was found to be significantly more effective than nitrazepam in inducing and maintaining sleep and in increasing its overall duration. The patients' subjective preference, reflecting the depth of sleep experienced and the effect of the medication, reached highly significant levels in favour of triazolam. Later in the study the differences between the drugs disappeared although the depth of sleep as judged in the study was better with triazolam.