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Serum concentrations of cis(Z)‐ and trans(E)‐clopenthixol after administration of cis(Z)‐clopenthixol and clopenthixol to human volunteers
Author(s) -
AaesJørgensen T.
Publication year - 1981
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1981.tb06215.x
Subject(s) - half life , cis–trans isomerism , pharmacology , chemistry , drug administration , high performance liquid chromatography , pharmacokinetics , medicine , stereochemistry , chromatography
The serum concentrations of cis(Z)‐ and trans(E)‐clopenthixol have been estimated in human volunteers by an HPLC‐method after administration of a clopenthixol tablet, which contains the cis(Z)‐ and the trans(E)‐isomers in the ratio 1/2, or a cis(Z)‐clopenthixol tablet. The serum concentration curves obtained for the cis(Z)‐isomer after administration of the two drug preparations were very similar, and thus independent of the presence of the trans(E)‐isomer in one of the preparations. Likewise the biological half‐lives and the areas under the serum concentration curves for cis(Z)‐clopenthixol were similar after the two preparations. The biological half‐life of cis(Z)‐clopenthixol was as a mean 20 hours (12–29 hours) indicating that from a pharmacokinetic point of view a dosage interval of 24 hours is possible for most patients. The biological half‐life of trans(E)‐clopenthixol is found to be longer than that for cis(Z)‐clopenthixol.