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A double‐blind comparison of the effects of haloperidol and cis(Z)‐clopenthixol in senile dementia
Author(s) -
Götestam K. G.,
Ljunghall S.,
Olsson B.
Publication year - 1981
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1981.tb06213.x
Subject(s) - haloperidol , double blind , dementia , significant difference , medicine , psychology , anesthesia , psychiatry , placebo , pathology , alternative medicine , disease , dopamine
ABSTRACT The therapeutic effects in senile dementia of haloperidol and cis(Z)‐clopenthixol were compared in a double‐blind, double‐dummy clinical 8‐week study in 47 demented patients after wash‐out periods of 3 weeks or less. Forty patients, most of whom received 0.5 mg haloperidol or 5 mg cis(Z)‐clopenthixol, completed the study in which assessments with the geriatric rating scales of Gottfries‐Cronholm and Crichton in addition to CGI were done at weeks ‐3, 0, 1, 2, 4, and 8. With the Gottfries‐Cronholm Scale few significant changes from week 0 were seen in the two groups of patients. Significant deteriorations at weeks 1 and 8 in the haloperidol group were, however, registered. The only significant difference between the two groups of patients regarded motor activity which was most positively influenced by cis(Z)‐clopenthixol. Accordingly, most results suggesting a difference between the two test drugs were in the favour of cis(Z)‐clopenthixol. With the Crichton and the CGI scales changes in the over‐all impression of the patients were very few. Side effects were mild and transient.