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Genetic models of sex effect in unipolar affective illness
Author(s) -
Baron M.
Publication year - 1981
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1981.tb00762.x
Subject(s) - psychology , inheritance (genetic algorithm) , genetic model , clinical psychology , psychiatry , genetics , biology , gene
Family study data on unipolar affective illness are analyzed by multiple threshold models of inheritance that incorporate sex effect. In these models maies and females share a common geneticenvironmental liability, but the less prevalent sex, i.e., males, has a higher genetic threshold for the disorder. Neither single major locus (SML) nor multifactorial‐polygenic (MFP) transmission can account for the sex differences in the morbid risk for unipolar disorder. The implications for genetic research in affective disorders are discussed.