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Zimelidine: Comparison of different dosage regimes in general practice
Author(s) -
Watson Joyce M.,
Tiplady Brian
Publication year - 1981
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1981.tb00753.x
Subject(s) - checklist , medicine , adverse effect , morning , rating scale , depression (economics) , hamilton rating scale for depression , antidepressant , hamilton depression scale , major depressive disorder , psychiatry , psychology , significant difference , anxiety , cognition , economics , cognitive psychology , developmental psychology , hamd , macroeconomics
Various studies have demonstrated that depressive symptoms are a frequent and important problem in general practice. Zimelidine has been shown to have effective antidepressant activity. A controlled double‐blind trial was set up to compare the efficacy and side effects of zimelidine when given as a single daily dose (200 mg night or morning) and when given as a divided dose (100 mg b.d.). These three dosage schedules were studied. The trial was conducted among patients attending their general practitioners and suffering from a depressive disorder. Using one of the three dosage schedules, these patients were treated with zimelidine for a minimum period of 6 weeks. Symptom severity was measured by means of the Hamilton Rating Scale for Depression and the side effects assessed using an adverse event record and a symptom checklist. The findings are discussed.