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Beta‐adrenergic stimulation and antidepressant activity
Author(s) -
Lecrubier Y.,
Puech A. J.,
Frances H.,
Jouvent R.,
Widlöcher D.,
Simon P.
Publication year - 1981
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1981.tb00718.x
Subject(s) - antidepressant , adrenergic receptor , beta (programming language) , salbutamol , stimulant , adrenergic , stimulation , medicine , pharmacology , endocrinology , receptor , psychology , asthma , computer science , hippocampus , programming language
The results presented here, together with the literature data, support the noradrenergic hypothesis of depressive states, and especially the involvement of beta‐adrenergic receptors: – In animals, beta stimulants have the same spectrum of activity as other antidepressants. – These effects of both classical antidepressants and beta‐adrenergic stimulants are antagonized by beta blockers. – Chronic administration of antidepressants results in a decrease of beta receptors. – Salbutamol, a beta‐adrenergic stimulant has, in depressed patients, a clear and rapid antidepressant effect.