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Lymphocyte subpopulations in peripheral blood from schizophrenic patients
Author(s) -
Yyland H.,
Néss A.,
Lunde H.
Publication year - 1980
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1980.tb00584.x
Subject(s) - schizophrenia (object oriented programming) , peripheral blood , medicine , lymphocyte , immunology , rosette (schizont appearance) , immune system , peripheral , receptor , t lymphocyte , peripheral blood lymphocyte , psychiatry
Patients with acute and chronic schizophreniz were examined for T andFc receptor‐bearing lymphocytes in blood by means of rosette techniques. The patients had normal numbres of peripheral blood lumphocyte. The percentage iof T lymphocytes in patients with acute schizophrenia was reduced (60 ± 2%) comlpared with controls (66 ± 1 %) and patients with chronic schizophrenia (67 ± 3 %). The total number of T lymphocytes was significantly decreased in patients with acute schizophrenia (1, 238 ± 89 cells/mm 3 , p <0.02) compared with controls (1, 538 ± 157 cells/mm 3 ), while patients with chronic schizophrenia had slightly elevated numbers (1, 778 ± 200 cells/mm 3 ). the percentage and total numbers of Fc receptor‐bearing lumphocutes were normal in both patients groups. Both immune mechanisms and the neuroplepic drug treatment may be of importance of the observed decrease in T lymphocyte numbers in blood from patients with acute schizophrenia.