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Single versus divided daily dosages of clomipramine
Author(s) -
Dencker S. J.,
Nagy A.
Publication year - 1979
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1979.tb06971.x
Subject(s) - clomipramine , dose , medicine , metabolite , anesthesia , plasma levels
Sixteen depressed patients have been treated with a daily dose of 150 mg clomipramine for 20 days. Every patient received the total dose at night for 10 days and three times daily for 10 days according to a double‐blind, cross‐over design. No differences were noted between the two dose regimens, either regarding the clinical effect or the side effects. The plasma level ratio of parent drug to demethylated metabolite was higher on single than multiple doses.