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Comparison of Vivalan (viloxazine hydrochloride) with imipramine in the treatment of depression
Author(s) -
Santonastaso P.,
Maistrello I.,
Battistin L.
Publication year - 1979
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1979.tb03580.x
Subject(s) - anticholinergic , imipramine , depression (economics) , medicine , significant difference , anesthesia , alternative medicine , pathology , economics , macroeconomics
Twenty‐eight hospitalized patients with depressive illness entered a double‐blind trial to compare viloxazine hydrochloride (VivalanrG) with imipramine. Both drugs produced a statistically significant improvement in the depressive symptoms as early as the 7th day, measured by the HRS. A side effects check‐list showed no significant difference between Vivalan and imipramine. A lack of anticholinergic effects was noted in the Vivalan group although upper gastro‐intestinal side effects were more frequent. Two patients in the Vivalan group withdrew due to gastric symptoms.