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Thyroid hormones and TSH, prolactin and LH responses to repeated TRH and LRH injections in depressed patients
Author(s) -
Linnoila M.,
Lamberg B.A.,
Rosberg G.,
Karonen S.L.,
Welin M. G.
Publication year - 1979
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1979.tb00254.x
Subject(s) - medicine , prolactin , endocrinology , radioimmunoassay , trh stimulation test , placebo , hormone , thyrotropin releasing hormone , thyroid hormones , alternative medicine , pathology
Twelve patients with unipolar depressive disorders received 600 μg of synthetic TRH or LRH, in a random order, for 3 days each. Placebo injections were given as two 3‐day courses prior to and between the active treatments. Serum TSH, prolactin (Prl) and LH were measured by radioimmunoassays prior to the experiment as well as immediately before and 20 min after each injection. Serum T 4 and T 3 were determined by radioimmunoassays before the treatments and 24 h after the first two TRH injections. Serum T 4 level in depressed patients did not differ from controls. Serum T 3 level in depressed patients was significantly below, and the reverse T 3 level was slightly above the normal mean. However, the latter difference was not statistically significant due to the large variation of rT 3 levels among the depressed patients. The TSH responses did not differ from that of controls after the first injection but the responses after the second injection were lower than in a control study. The Prl responses to TRH were subnormal in seven out of eight patients. Blunted LH responses to LRH were seen in three patients.