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Comparative trial of amitriptyline‐N‐oxide and amitriptyline in the treatment of out‐patients with depressive syndromes
Author(s) -
Rapp W.
Publication year - 1978
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1978.tb06936.x
Subject(s) - amitriptyline , anticholinergic , orthostatic vital signs , depression (economics) , antidepressant , sedative , medicine , anesthesia , side effect (computer science) , psychology , blood pressure , computer science , hippocampus , economics , macroeconomics , programming language
Amitriptyline‐N‐oxide and amitriptyline were compared double‐blind in a material of out‐patients with depressive syndromes, 21 and 22 patients respectively. Both drugs had a good antidepressant effect. The globally rated effect was equal. The effect upon the various depressive symptoms was equal. Definite reversal of depression occurred somewhat earlier on amitriptyline‐N‐oxide on which side effects were also less marked, both those of an anticholinergic and of a sedative nature. No orthostatic reaction, nor any effect upon blood status or liver function, was observed. Amitriptyline‐N‐oxide appears to show a tendency to a some‐what more rapid onset of effect and less side effects.