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High doses of fluphenazine enanthate in schizophrenia: A CONTROLLED STUDY
Author(s) -
Dencker S. J.,
Johansson R.,
Lundin L.,
Malm U.
Publication year - 1978
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1978.tb06909.x
Subject(s) - fluphenazine , schizophrenia (object oriented programming) , psychopathology , refractory (planetary science) , extrapyramidal symptoms , medicine , psychosis , psychology , psychiatry , anesthesia , antipsychotic , haloperidol , physics , astrobiology , dopamine
The results from this controlled study of 12 schizophrenics refractory to ordinary doses of neuroleptics indicate that treatment with fluphenazine enanthate in higher doses than normal (10–20 times higher) might give reduction in psychopathology beyond what can be obtained with normal doses. In four patients the symptom reduction on high doses was pronounced. Moreover, we found that the high fluphenazine plasma levels demonstrated did not increase extrapyramidal and general side effects. The results presented also speak in favour of certain “non‐responding” patients needing a higher plasma level of a neuroleptic drug than the average patient.