Premium
Comparative evaluation of hypnotic efficacy of flunitrazepam in psychiatric in‐patients
Author(s) -
Singer K.,
Lo C. W.,
Tam Y. K.
Publication year - 1978
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1978.tb06907.x
Subject(s) - flunitrazepam , nitrazepam , flurazepam , hypnotic , psychiatry , medicine , sleep (system call) , sedative/hypnotic , anesthesia , psychology , benzodiazepine , diazepam , receptor , computer science , operating system
Flunitrazepam in 2‐mg and 4‐mg doses was compared with flurazepam 30 mg and nitrazepam 10 mg for hypnotic efficacy in a double‐blind, multiple cross‐over trial involving 41 psychiatric in‐patients. In the vast majority of comparisons involving a number of sleep parameters differences did not reach significance level. Flunitrazepam 4 mg tended to produce the shortest latency time and the longest duration of sleep but also the most side‐effects. Nitrazepam 10 mg appeared to have a slight advantage over the other drugs in terms of patient preference. For severe sleep disturbance flunitrazepam 2 mg tended to be the most satisfactory drug in terms of efficacy and paucity of side‐effects.