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Addition of L‐tryptophan to electroconvulsive treatment in endogenous depression
Author(s) -
Kirkegaard C.,
Mosller S. E.,
Bjosrum N.
Publication year - 1978
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1978.tb03576.x
Subject(s) - electroconvulsive therapy , tryptophan , placebo , depression (economics) , endogeny , endogenous depression , cerebrospinal fluid , saline , medicine , psychology , significant difference , anesthesia , chemistry , electroconvulsive shock , biochemistry , alternative medicine , pathology , economics , macroeconomics , amino acid
The combination of electroconvulsive treatment (ECT) and i.v. Ltryptophan (T) was compared with ECT and saline in a doubleblind study comprising 20 patients with endogenous depression. No significant difference was found with regard to the number of ECT given nor in the rate of reduction of depressive symptoms. Except for a slight decrease of plasma total tryptophan in the placebo group, no difference were found in plasma total and free tryptophan nor in the concentration of total tryptophan in the cerebrospinal fluid.