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Biochemical and pharmacological properties of oxazepam
Author(s) -
GARATTINI S.
Publication year - 1978
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1978.tb02382.x
Subject(s) - oxazepam , in vivo , pharmacology , chemistry , in vitro , biochemistry , medicine , biology , benzodiazepine , receptor , microbiology and biotechnology
Oxazepam is the final metabolic product in vitro and in vivo of a large number of pharmacologically active benzodiazepines. Oxazepam shows antimetrazol activity varying in intensity and duration according to the animal species considered. This difference is in part related to different “sensitivity and in part due to different disposition of oxazepam. Particularly relevant is the difference in biliary excretion by various animal species. Oxazepam is currently available as a racemate but two optical isomers can be separated as succinate half esters. The (+) form appears to bc more active than the (‐) form, probably because more oxazepam is released from the (+) than the (‐) isomerin vivo. In vitro studies confirm that the liver hydrolyzes the (+) oxazcpam succinate half ester more than the (‐) form. Other work has aimed at analyzing the effects of oxazepam on brain chemical mediators, with particular reference to the cholinergic system. Finally it is shown that oxazeparn, similarly to other benzodiazepines. increased aggressiveness in male mice during chronic treatment.