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Effects of ACTH 4–10 on ECT‐induced memory dysfunctions
Author(s) -
Small J. G.,
Small I. F.,
Milstein V.,
Dian D. A.
Publication year - 1977
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1977.tb00169.x
Subject(s) - placebo , psychology , dose , adrenocorticotropic hormone , memory disorder , psychiatry , medicine , cognitive disorder , hormone , cognition , pathology , alternative medicine , cognitive impairment
Double‐blind studies of ACTH 4–10 and placebo were conducted in psychiatric patients receiving bilateral ECT to determine whether the polypeptide exerted anti‐amnesic effects. Observations after a single ECT were suggestive of some positive effects, but studies between seizures after five or six ECTs showed no significant drug‐placebo differences. Although the findings were largely negative, they do not rule out positive effects of ACTH 4–10 on memory. Possibly the designs and timing of the experiments and/or the dosages of ACTH 4–10 employed were unsuitable for demonstrating such influences.