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Thyrotropin‐Releasing Hormone (TRH) in chronic schizophrenia: A CONTROLLED STUDY
Author(s) -
Lindström L. H.,
Gunne L.M.,
ÖSt L.G.,
Persson E.
Publication year - 1977
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1977.tb00142.x
Subject(s) - placebo , thyrotropin releasing hormone , medicine , hormone , trh stimulation test , schizophrenia (object oriented programming) , endocrinology , placebo group , psychology , psychiatry , alternative medicine , pathology
A controlled study on the effect of synthetic Thyrotropin‐Releasing Hormone (TRH) versus placebo in 10 drug‐free chronic schizophrenics is presented TRH 600 μg or placebo was administered intravenously on 4 consecutive days in a double‐blind cross‐over design and the schizophrenic symptoms were scored daily by use of two rating scales (CPRS and NOSIE). Blood samples were taken before and 30 and 45 minutes after the first and the fourth injection an analyzed for TSH. No changes in symptom intensity were found during the TRH or placebo treatment period and no difference was obtained between the two treatments. The dose of TRH used caused a significant increase in the plasma level of TSh which indicated a normal pituitary responsiveness to TRH. The data do not support the notion that TRH has a beneficial effect in chronic schizophrenic patients.