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LITHIUM EFFECTS ON DIURNAL RHYTHM OF CALCIUM, MAGNESIUM, AND PHOSPHATE METABOLISM IN MANIC‐MELANCHOLIC DISORDER
Author(s) -
Mellerup E. T.,
Lauritsen B.,
Dam H.,
Rafaelsen O. J.
Publication year - 1976
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1976.tb00084.x
Subject(s) - calcium , excretion , lithium (medication) , magnesium , endocrinology , medicine , circadian rhythm , urine , chemistry , phosphate , urinary system , blood plasma , biochemistry , organic chemistry
The diurnal rhythm of plasma phosphate, calcium, and magnesium was studied in 34 lithium treated patients, in 42 other psychiatric patients, and in 47 healthy persons. Seventeen blood samples were drawn from each person during the 24‐hour period. Lithium was given at 10 p.m. and in the next few hours plasma phosphate decreased compared with the two control groups. In the same period plasma calcium showed a temporary increase, whereas plasma magnesium was increased during the whole 24‐hour period. The lithium treated patients had a reduced urinary calcium excretion during the night, and an increased urinary magnesium excretion during the day, whereas no changes were found in urinary phosphate excretion.