Premium
PROGNOSTIC VALUE OF THYROTROPIN‐ RELEASING HORMONE STIMULATION TEST IN ENDOGENOUS DEPRESSION
Author(s) -
Kirkegarrd C.,
Nørlem N.,
Lauridsen U. B.,
Bjørum N.
Publication year - 1975
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1975.tb00034.x
Subject(s) - thyrotropin releasing hormone , trh stimulation test , medicine , depression (economics) , endocrinology , endogeny , stimulation , triiodothyronine , hormone , endogenous depression , confidence interval , hypothalamic–pituitary–thyroid axis , economics , macroeconomics
Throtropin‐releasing hormone (TRH) stimulation tests were performed in 19 patients with endogenous depression before treatment and when they had apparently recovered following antidepressive treatment. An increase in the maximal serum thyrotropin (TSH) response to TRH of more than 2.0 μU/ml was found in all of ten patients who did not relapse, while such an increase was found in only one of nine patients who did relapse within 6 months. I. e., a correct prognosis was posible in 94.7% (95% confidence limits 74.0 ‐ 99.9%). Though significant changes were found in serum thyroxine (T4), free T4 index, serum triiodothyronine (T3) and free T3 index, these fidings were of no prognostic value.