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PENFLURIDOL (R 16 341) AS A MAINTENANCE THERAPY IN CHRONIC PSYCHOTIC PATIENTS: A DOUBLE‐BLIND CLINICAL EVALUATION
Author(s) -
Roelofs G. A.
Publication year - 1974
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1974.tb08210.x
Subject(s) - placebo , double blind , medicine , clinical trial , placebo group , physical therapy , alternative medicine , pathology
A double‐blind, 6‐month trial of penfluridol and placebo was conducted in 15 chronic psychotic patients in the age range of 25–64 years. The patients, who had been well controlled with penfluridol for several months, were divided into two comparable groups with seven patients receiving penfluridol and eight receiving placebo. Dexetimide and other non‐psychotropic drugs already taken before the trial were continued. Each patient was assessed before and after 1, 2, 4 and 6 months of treatment using a 36‐item questionnaire. At the end of the trial, the weekly dosage of the double‐blind medication was two tablets of 20 mg or placebo in all patients. Whereas penfluridol‐treated patients maintained their improvement, placebo‐treated patients by the end of the trial had significantly deteriorated as regards direct psychotic phenomena and general behaviour.