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THE EFFECTS OF LITHIUM CARBONATE ON SERUM GASTRIN IN PSYCHIATRIC PATIENTS
Author(s) -
Sathananthan G.,
Shopsin B.,
Petersson B.
Publication year - 1974
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1974.tb07660.x
Subject(s) - gastrin , lithium (medication) , medicine , lithium carbonate , endocrinology , g cell , chemistry , secretion , ion , organic chemistry , ionic bonding
Indications that gastrin is produced in the pancreatic A 1 cells and that there is a lithium‐related increase in A 1 cell nuclei in guinea pigs are background factors leading up to this study. The effect of lithium treatment on the gastrin level in serum was tested on four patients with different psychiatric diagnoses. All the patients showed normal serum values during the first 3 weeks of the treatment period. Possible reasons for the relatively unelevated levels of serum gastrin (non‐detectable to 300 pg gastrin/ml serum) are discussed. The effects of catecholamines on gastrin release is also mentioned as a lead in the study of the relationships between lithium, amines, gastrin and carbohydrate metabolism.