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A CONTROLLED TRIAL OF COMBINED MEDICATIONS ON BEHAVIORAL AND EXTRAPYRAMIDAL EFFECTS
Author(s) -
SIMPSON G. M.,
B. M.,
B. CH.,
KRAKOV L.,
D. M.,
KUNZBARTHOLINI ESTHER,
D. M.
Publication year - 1970
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1970.tb02067.x
Subject(s) - perphenazine , double blind , extrapyramidal symptoms , dose , crossover study , medicine , amitriptyline , therapeutic effect , psychology , anesthesia , psychiatry , pharmacology , schizophrenia (object oriented programming) , antipsychotic , placebo , alternative medicine , pathology
SUMMARY Under double‐blind conditions, increasing amounts of perphenazine, or a perphenazine‐amitriptyline combination, were given to chronic schizophrenic patients already receiving “optimal” therapeutic dosages of perphenazine. Slight behavioral improvement was obtained in both groups, but a significantly smaller amount of extrapyramidal side effects was noted in the group receiving the combination. A double‐blind crossover study was used, which eliminated any order effect. The implications of these findings for therapy are briefly discussed.