Open AccessOcular complications in a child with acute graft‐versus‐host disease following cord blood stem cell transplantation: therapeutic challenges
Author(s) -
Uchino Miki,
Ogawa Yoko,
Kawai Masataka,
Shimada Hiroyuki,
Kameyama Kaori,
Okamoto Shinichiro,
Dogru Murat,
Tsubota Kazuo
Publication year - 2006
Publication title -
acta ophthalmologica scandinavica
Language(s) - English
Resource type - Journals
eISSN - 1600-0420
pISSN - 1395-3907
DOI - 10.1111/j.1600-0420.2006.00658.x
Subject(s) - medicine , histopathology , transplantation , stem cell , graft versus host disease , cornea , cord blood , surgery , pathology , ophthalmology , biology , immunology , genetics
Abstract We present the first child case of pseudomembranous conjunctivitis accompanied by an extensive corneal ulcer with acute graft‐versus‐host disease (GVHD) after cord blood stem cell transplantation (CBSCT). The histopathology of the pseudomembrane and the ocular changes following its excision were investigated specifically. One week after the excision of pseudomembrane, the extensive corneal epithelial defects had totally disappeared. Pseudomembrane excision may be an effective method of treatment in corneal epithelial defects observed after GVHD.