Open AccessEffect of voriconazole on a corneal abscess caused by fusarium
Author(s) -
Polizzi Anna,
Siniscalchi Cristina,
Mastromarino Antonio,
Saccà Sergio C.
Publication year - 2004
Publication title -
acta ophthalmologica scandinavica
Language(s) - English
Resource type - Journals
eISSN - 1600-0420
pISSN - 1395-3907
DOI - 10.1111/j.1600-0420.2004.00366.x
Subject(s) - medicine , voriconazole , fluconazole , fusarium solani , abscess , surgery , corneal ulcer , antifungal , dermatology , keratitis , microbiology and biotechnology , biology
. Purpose: To describe a case of corneal abscess caused by Fusarium solani that did not respond to common antifungal agents. Method: Case report. Results: Twenty days after accidental contact with vegetation, a 56‐year‐old man presented with a corneal abscess. Corneal ulceration developed and a perforating keratoplasty was performed. After a microbiological examination, the diagnosis of F. solani infection was made. Systemic and topical amphotericin B and fluconazole were prescribed, with no results. A new abscess formed on the transplanted graft and a wound leak developed. We administered topical and systemic voriconazole. No side‐effects were observed. The choroidal detachment and the surgical transplant recovered completely in 20 days. A vascular leukoma developed at the site of the transplanted corneal abscess. Conclusion: From a functional point of view, another corneal transplant will be necessary. Voriconazole was effective in treating a severe keratomycosis caused by F. solani that was resistant to other topical and systemic antifungal agents.