Open AccessChemokine receptors and early activation markers in acute anterior uveitis
Author(s) -
Sørensen Klitgaard Torben L.,
Øgard Carsten,
Krogh Erik
Publication year - 2004
Publication title -
acta ophthalmologica scandinavica
Language(s) - English
Resource type - Journals
eISSN - 1600-0420
pISSN - 1395-3907
DOI - 10.1111/j.1600-0420.2004.00251.x
Subject(s) - medicine , anterior uveitis , receptor , chemokine , ophthalmology , uveitis
. Purpose: To study the peripheral expression of chemokine receptors and early activation markers in acute anterior uveitis (AU). Methods: The expression of chemokine receptors CCR1, CCR2, CCR3, CCR5 and CXCR3, and activation markers CD25 (IL2R‐α‐chain), CD122 (IL2R‐β‐chain) and CD69 were studied on peripheral blood mononuclear cells using flow cytometry in 10 patients with acute anterior uveitis and in 10 healthy controls. Results: We found a highly significant up‐regulation of CCR5 (p < 0.001) on CD4 + T‐cells in the blood of patients with AU compared to in healthy controls. CD69 was significantly higher on both CD4 + and CD8 + T‐cells (p < 0.05 and p < 0.001, respectively). We also found a significantly higher expression of CD25 expressing CD4 + T‐cells in patients with anterior uveitis (p < 0.05). This expression was directly correlated to the severity of disease ( ρ = 0.720, p < 0.05). Conclusion: Our data show that patients with acute anterior uveitis have a specific systemic immune activation.