Open AccessAssessment of chamber angle pigmentation during longterm latanoprost treatment for open‐angle glaucoma
Author(s) -
Nakamura Yuko,
Nakamura Yoshimi,
MorineShinjo Sayo,
Sakai Hiroshi,
Sawaguchi Shoichi
Publication year - 2004
Publication title -
acta ophthalmologica scandinavica
Language(s) - English
Resource type - Journals
eISSN - 1600-0420
pISSN - 1395-3907
DOI - 10.1111/j.1600-0420.2004.00243.x
Subject(s) - medicine , latanoprost , glaucoma , ophthalmology , open angle glaucoma , quadrant (abdomen) , intraocular pressure , iris (biosensor) , anterior chamber angle , ocular hypertension , surgery , computer security , computer science , biometrics
. Purpose: This study aimed to determine whether the longterm use of latanoprost is associated with an increase in trabecular pigmentation, especially in subjects in whom iris pigmentation has increased. Methods: We enrolled 50 subjects for whom treatment was to start for ocular hypertension, primary open‐angle glaucoma or normal tension glaucoma. All subjects received latanoprost 0.005% daily. Trabecular pigmentation was documented using gonioscopic photography of the inferior quadrant at baseline, every 3 months for the first year and every 6 months for the second and third years. Three glaucoma specialists evaluated the series of gonioscopic photographs for each eye of each subject in a masked fashion. The intraocular pressure (IOP) was also recorded at each visit. Results: A total of 41 subjects (79 eyes) completed 3 years of follow‐up, and none showed any increase in the grade of trabecular pigmentation, including 10 subjects (20 eyes) in whom the iridial pigment increased. Conclusion: Although latanoprost increased iridial pigmentation in some subjects, we found no evidence of an increase in trabecular pigmentation over the 3 years of follow‐up.