Open AccessThe importance of plasma polymorphonuclear (PMN) elastase determination in patients with uveitis
Author(s) -
Akyol Nurettin,
Deĝer Orhan,
Erdöl Hidayet,
Gedik Yusuf,
Örem Asim,
Imamoglu Halil Ibrahim
Publication year - 1997
Publication title -
acta ophthalmologica scandinavica
Language(s) - English
Resource type - Journals
eISSN - 1600-0420
pISSN - 1395-3907
DOI - 10.1111/j.1600-0420.1997.tb00775.x
Subject(s) - medicine , elastase , uveitis , neutrophil elastase , immunology , polymorphonuclear leukocyte , gastroenterology , inflammation , enzyme , in vitro , biochemistry , chemistry
Purpose: Polymorphonuclear elastase is used as an important marker for inflammatory disease. We wanted to show whether polymorphonuclear elastase could be a marker in uveitis. Methods: Twenty‐two patients with uveitis and 30 healthy control subjects were included in the study. Polymorphonuclear elastase levels were determined by immunoactivation method before and after periods of corticosteroid and/or ciclosporin treatments. Results: The levels were high in all of the patients before treatment; the levels reached normal range with treatment. In some cases, however, uveitis could not be suppressed in spite of treatment; these patients had high polymorphonuclear elastase levels. Conclusion: It was concluded that determination of polymorphonuclear elastase level may be used for monitoring of uveitis.