Open AccessA leiomyoma of the iris documented by immunohistochemistry and electron microscopy
Author(s) -
Eide Nils,
Farstad Inger Nina,
Røger Magnus
Publication year - 1997
Publication title -
acta ophthalmologica scandinavica
Language(s) - English
Resource type - Journals
eISSN - 1600-0420
pISSN - 1395-3907
DOI - 10.1111/j.1600-0420.1997.tb00417.x
Subject(s) - desmin , immunohistochemistry , pathology , electron microscope , leiomyoma , iris (biosensor) , medicine , anatomy , cytoplasm , biology , vimentin , microbiology and biotechnology , computer science , physics , computer security , biometrics , optics
Purpose : To report an iris leiomyoma documented in accordance with today's stricter diagnostic criteria. Methods : Light microscopy, immunohistochemistry and electron microscopy were performed on the 3 mm ball‐like, greyish‐white vascularized tumour of the iris, close to the sphincter pupillae. Results : Light microscopy of the extirpated neoplasm showed the characteristic appearance of a leiomyoma with densely packed spindle‐shaped cells, with oval nuclei and granular cytoplasm. On electron microscopic examination the tumour exhibited the characteristic features of a smooth muscle neoplasm. The immunohistochemistry was consistent with a myogenic tumour because the tumour cells were positive for smooth muscle actin and desmin, but negative for S‐100 and melanin. Conclusion : The case illustrated the necessity of performing ancillary procedures such as electron microscopy and immunohistochemistry to substantiate a correct, although rare diagnosis.