Open AccessSignificant decrease in maternal serum concentrations of angiopoietin‐1 and ‐2 after delivery
Author(s) -
KEIKKALA ELINA,
HYTINANTTI TIMO,
WATHÉN KATJAANNELI,
ANDERSSON STURE,
VUORELA PIIA
Publication year - 2012
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/j.1600-0412.2012.01463.x
Subject(s) - medicine , population , amniotic fluid , urine , endocrinology , umbilical cord , pregnancy , fetus , immunology , biology , genetics , environmental health
Objective. To characterize the physiological distribution of angiopoietins (Ang)‐1 and Ang‐2 and soluble endothelial cell‐spesific tyrosine kinase receptor‐2 (Tie‐2) at term and following delivery. Design. A prospective, descriptive study. Setting. Helsinki University Central Hospital. Population. Twenty healthy term pregnant women undergoing elective cesarean delivery and their newborns. Methods . The concentrations were analysed by enzyme‐linked immunosorbent assay in maternal antepartum and the first postpartum day sera, umbilical serum, amniotic fluid and maternal and newborn urine. Main outcome measures. Concentrations of Ang‐1, Ang‐1 and Tie‐2. Results . Concentrations of maternal serum Ang‐1 and Ang‐2 decreased after delivery {[median (range)]: Ang‐1, from 33 (25–51) to 30 (18–49) ng/mL, p = 0.017; and Ang‐2, from 5.4 (1.8–18) to 1.4 (0.7–4.6) ng/mL, p < 0.0001}, whereas Tie‐2 concentrations remained stable [23 (13–41) vs. 25 (14–29) ng/mL, p = 0.107]. Compared with maternal antepartum serum, umbilical serum concentrations of Ang‐1 [46 (28–59) ng/mL, p < 0.0001] and Tie‐2 [45 (21–71) ng/mL, p < 0.0001] were higher and those of Ang‐2 similar [5.4 (1.8–18) vs. 4.2 (2.9–6.0) ng/mL; p = 0.067]. Low concentrations of Ang‐1 [1.2 (0.1–2.2) ng/mL], Ang‐2 [1.1 (0.3–4.1) ng/mL] and Tie‐2 [0.4 (0.08–0.9) ng/mL] were observed in amniotic fluid, but they were undetectable in newborn urine and in most of the maternal urine samples. Conclusions. Maternal Ang‐1 and Ang‐2 concentrations decreased following delivery. Umbilical concentrations of Ang‐1 and Tie‐2 were higher than the maternal concentrations.