Open AccessMaternal weight gain in twin–twin transfusion syndrome
Author(s) -
MORIKAWA MAMORU,
YAMADA TAKASHI,
HIRAYAMAKATO EMI,
YAMADA TAKAHIRO,
OKUYAMA KAZUHIKO,
MINAKAMI HISANORI
Publication year - 2011
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/j.1600-0412.2011.01254.x
Subject(s) - weight gain , medicine , birth weight , gestational age , obstetrics , observational study , gestation , twin twin transfusion syndrome , prospective cohort study , pregnancy , pediatrics , body weight , fetus , biology , genetics
Objective . To examine the association between maternal weight gain and twin–twin transfusion syndrome (TTTS). Design . Retrospective observational study in two tertiary care centers. Population . All 124 women with monochorionic diamniotic twin pregnancies who gave birth at ≥16 gestational weeks between 2002 and 2010. Methods . Analysis of chronological relation between maternal weight gain per week (weekly gain) and the diagnosis of TTTS. Main outcome measure . Sonographic diagnosis of TTTS. Results . A weekly weight gain ≥1.4 kg occurred in 45 women, preceded the diagnosis of TTTS in 22 (78.6%) of the 28 women with TTTS, and was associated with TTTS [women with one weekly weight gain ≥1.4 kg vs. women with no weekly weight gains ≥1.4 kg who were diagnosed as having TTTS: 48.9% (22/45) vs. 7.6% (6/79); RR, 6.44; 95%CI, 2.82–14.69]. At given gestational weeks between 16 and 27, the mean (±SD) prospective risk of the development of TTTS within three weeks was 52.0±33.8% among women who showed a weekly weight gain ≥1.4 kg for the first time, whereas the risk of the development of TTTS within one week was 1.6±1.7% among women who never showed a weekly weight gain ≥1.4 kg. Conclusions . Excessive maternal weight gain ≥1.4 kg/week is likely to occur during the development of TTTS.