Open AccessPrevalence of human papillomavirus in spontaneously aborted products of conception
Author(s) -
SKOCZYŃSKI MARIUSZ,
GOŹDZICKAJÓZEFIAK ANNA,
KWAŚNIEWSKA ANNA
Publication year - 2011
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/j.1600-0412.2011.01189.x
Subject(s) - medicine , abortion , obstetrics , pregnancy , human papillomavirus , gynecology , hpv infection , products of conception , polymerase chain reaction , cancer , cervical cancer , gene , biology , genetics
Objective . To compare the prevalence of human papillomavirus (HPV) in placentas from women with spontaneous abortions and from control women after term delivery. Design . Cross‐sectional study. Setting . Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin (Poland). Population . Patients whose spontaneous abortions occurred between the 6th and the 16th week of pregnancy ( n =51), and women after term delivery ( n =78). Method . Polymerase chain reaction (PCR). Main outcome measures . HPV DNA prevalence rate and the fraction of HPV 16/18 infections in aborted products of conception and placentas. Results . Patients with spontaneous abortion did not differ from the controls in terms of mean age and the fraction of primiparas. The DNA of HPV was detected in 17.7% of aborted products of conception and in 24.4% of placentas from term deliveries. The aborted products of conception and full‐term placentas were positive for HPV 16/18 in 11.8 and 12.8% cases, respectively. Patients whose material was positive for HPV DNA or those with confirmed HPV 16/18 did not differ significantly from HPV‐negative women in terms of mean age and the fraction of primiparas. Conclusions . The HPV 16/18 infection rate does not seem be higher in cases of spontaneous abortions. Nevertheless, further study of the consequences of HPV infection in pregnancy is still needed.