Open AccessPlasma lipocalin‐2 levels in pregnancy
Author(s) -
CESUR SEMRA,
YUCEL AYKAN,
NOYAN VOLKAN,
SAGSOZ NEVIN
Publication year - 2012
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/j.1600-0412.2011.01158.x
Subject(s) - medicine , body mass index , insulin resistance , lipocalin , overweight , endocrinology , pregnancy , insulin , adipokine , population , biology , genetics , environmental health
Objective. To evaluate plasma levels of lipocalin‐2, which is a novel adipokine associated with obesity and insulin resistance, in pregnant women. Design. Prospective case–control study. Setting. University hospital. Population. Pregnant women with pre‐pregnancy body mass index >25kg/m 2 (overweight; n =29) and body mass index <25kg/m 2 ( n =27), whose gestational ages were between 24 and 28weeks, as study groups and nonpregnant control women with body mass index <25kg/m 2 ( n =29). Methods. Plasma lipocalin‐2 levels, fasting plasma glucose and fasting plasma insulin levels; homeostasis model assessment insulin resistance index and fasting plasma glucose/fasting plasma insulin ratio were measured for each subject. Main Outcome Measures . Comparisons among the groups and correlations for lipocalin‐2 and the parameters of insulin resistance. Results. Plasma lipocalin‐2 levels among the pregnant women were significantly higher than those of the control group ( p <0.001 for both group comparisons). Lipocalin‐2 levels were significantly higher in the group with pre‐pregnancy body mass index >25kg/m 2 compared with the group with pre‐pregnancy body mass index <25kg/m 2 ( p =0.003). Lipocalin‐2 levels were positively correlated with homeostasis model assessment insulin resistance index and fasting plasma insulin and negatively correlated with fasting plasma glucose/fasting plasma insulin ratio in both pregnant groups. Conclusions. Lipocalin‐2 was found to be higher in pregnant women, especially when pre‐pregnancy body mass index was >25kg/m 2 , and it was correlated with markers of insulin resistance.