Open AccessTrends in incidence of borderline ovarian tumors in Denmark 1978–2006
Author(s) -
HANNIBAL CHARLOTTE GERD,
HUUSOM LENE DRASBEK,
KJAERBYETHYGESEN ANETTE,
TABOR ANN,
KJAER SUSANNE K.
Publication year - 2011
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/j.1600-0412.2010.01060.x
Subject(s) - medicine , incidence (geometry) , serous fluid , poisson regression , population , confidence interval , ovarian cancer , rate ratio , cohort , gynecology , demography , cancer , obstetrics , physics , environmental health , sociology , optics
Objective. To examine period‐, age‐ and histology‐specific trends in the incidence rate of borderline ovarian tumors in Denmark in 1978–2006. Design . Register‐based cohort study. Setting. Denmark 1978–2006. Population. 5 079 women diagnosed with a borderline ovarian tumor in at least one of two nationwide registries (4 312 epithelial tumors and 767 non‐epithelial/unspecified tumors). Methods. Estimation of overall incidence rates and period‐, age‐ and histology‐specific incidence rates. Age‐adjustment was done using the World Standard Population. To evaluate incidence trends over time, we estimated average annual percentage change and 95% confidence intervals (CI) using log‐linear Poisson models. Main Outcome Measures. Age‐standardized and age‐specific incidence rates and average annual percentage change. Results. The incidence of epithelial borderline ovarian tumors increased from 2.6 to 5.5 per 100 000 women‐years between 1978 and 2006, with an average annual percentage change of 2.6% (95% CI: 2.2–3.0). The median age at diagnosis was 52 years. Women 40 years or older had a higher average annual percentage change than women younger than 40 years. Most tumors were mucinous (49.9%) and serous tumors (44.4%). Women with mucinous tumors were younger at diagnosis (50 years) compared with women with serous tumors (53 years). Women with serous tumors had a higher average annual percentage incidence change than women with mucinous tumors. Conclusions. The incidence rate of borderline ovarian tumors increased significantly in Denmark in 1978–2006. In line with results for ovarian cancer, Denmark had a higher incidence rate of borderline ovarian tumors compared with the other Nordic countries in 1978–2006.