Open AccessLow‐risk human papillomavirus types 6 and 11 associated with carcinomas of the genital and upper aero‐digestive tract
Author(s) -
Turazza Estela,
Lapena Alicia,
Sprovieri Osvaldo,
Torres César Pires,
Gurucharri Carlos,
Maciel Alejandra,
Lema Baltasar,
Grinstein Saul,
Kahn Tomas
Publication year - 1997
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/j.1600-0412.1997.tb07858.x
Subject(s) - polymerase chain reaction , medicine , southern blot , carcinogenesis , carcinoma , pathology , sex organ , cancer , biology , dna , gene , genetics
Background. Human papillomavirus (HPVs) types 6 and 11, are frequently found in non‐malignant anogenital condylomas and laryngeal papillomas. However, in an ongoing epidemiological study in Argentina in which 163 anogenital and aero‐respiratory cancer biopsies were analyzed, several cases infected with low‐risk HPVs could be detected. Methods. Tumor samples were analyzed by Southern blot hybridization, using HPVs 6, 11, 16, 18, 30, 31, 33 and 35 as probes, and polymerase chain reaction (PCR) with type‐specific primers and probes. Results. Four invasive carcinomas containing HPV 6 or 11 could be detected (2.4%) by Southern blot technique. HPV 6 DNA was found in a penile carcinoma, a groin carcinoma, and in a tonsillar carcinoma. One cervical carcinoma harbored HPV 11 DNA. Using HPVs 6, 11, 16, 18 and 33 anticontamination primers and probes in PCR, no additional high‐risk HPV types could be detected in these four cancers. Conclusion. This report shows the presence of low‐risk HPVs (HPV 6 and 11) associated to malignant tumors in a frequency higher than usually observed. The data raise questions about which are the circumstances which may favor low‐risk HPV related oncogenesis.