Open AccessCalcium Antagonist Effect On Adhesion Formation
Author(s) -
Golan A.,
Wexler S.,
Lotan G.,
Abramov L.,
Langer R.,
David M. P.
Publication year - 1989
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/j.1600-0412.1989.tb07832.x
Subject(s) - diltiazem , antagonist , calcium , medicine , adhesion , pharmacology , endocrinology , receptor , chemistry , organic chemistry
In view of the role of the calcium ion in the inflammatory process, the effect of Diltiazem — a calcium antagonist—on the formation of intraperitoneal adhesions was studied in rats after induced trauma to the uterine serosa. It was found that intraperitoneal application of diltiazem inhibited adhesion formation to some extent, whereas intramuscularly administered Diltiazem did not. A dual effect of calcium antagonists on the formation of adhesions is suggested.