Open AccessThe Effect of Clomiphene Citrate and Tamoxifen on the Cervical Mucus
Author(s) -
Tepper Ron,
Lunenfeld Bruno,
Shalev Joseph,
Ovadia Jardena,
Blankstein Josef
Publication year - 1988
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/j.1600-0412.1988.tb07805.x
Subject(s) - medicine , cervical mucus , placebo , ovulation , follicular phase , endocrinology , clomifene , crossover study , tamoxifen , mucus , estrogen , ovulation induction , hormone , biology , cancer , ecology , alternative medicine , pathology , breast cancer
The anti‐estrogenic effect of clomiphene citrate (CC) and tamoxifen (TMX) on cervical mucus was evaluated in a prospective crossover study. Ten women underwent randomized alternate cyclical treatment with either 100 mg CC, 40 mg TMX daily, or with placebo. The effect of CC, TMX and placebo on serum estradiol (E 2 ), cervical mucus secretion and on the development of ovarian follicles was evaluated. Compared with placebo, treatment with CC and TMX significantly increased the number of mature ovarian follicles on the day of assumed ovulation (p <0.05), elevated E, secretion (p <0.05) and decreased cervical score (p <0.05). It can be concluded that anti‐estrogenic agents reduced the secretion of cervical mucus. However, in most cases, the excessive E, production due to multiple follicular growth overcomes the anti‐estrogenic effect.